A new modification of the CRISPR can edit up to 50 percent of the genome

Editor CRISPR genome has become a very important tool in medical research and may ultimately have a significant impact on various areas: from agriculture to treat a whole heap of hereditary diseases. However, it is far from perfect, as it can not edit any part of the DNA. But that could change thanks to new modifications, you are able to “give access” to almost half of the molecule.

The fact that is now used by a notorious bunch of CRISPR-Cas9 in which the last part acts as a “guidance system” on a particular portion of the DNA molecule. Cas9, or more specifically, Streptococcus Roodee Cas9 (SpCas9), by its very nature has very limited stretches of DNA to which it can influence. According to available information is about 9.9% of the total genome.

A group of researchers from mit led by Professor Joseph Jacobson found another enzyme that can extend the potential applications of CRISPR.

To do this, experts used computational algorithms for the search of bacterial sequences to determine whether there are any similar SpCas9 connection. In the end, was discovered a much more interesting Cap Streptococcus enzyme, called respectively ScCas9. Unlike his “brother” for his attachment to DNA is required instead of two G nucleotides only one. According to the authors,

“Enzyme looks almost identical to the one that was originally discovered, but it is able to target a much larger number of DNA sequences, which opens the way to a fuller editing of the genome. In addition, ScCas9 works with the same RNA and SpCas9. So you can easily use existing tools and best practices for future surveys.”

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