Born in China, the world’s first pig with cages of monkeys

Scientists for a long time (and sometimes even quite successfully) trying to get chimeras. If you do not go into the details, the chimeras are organisms composed of genetically different cells. If even easier, it looks the body looks like a creature of the same species (or very similar), but at the cellular level the animal has cells of another species. And, as the editors of the New Science magazine, not so long ago a group of Chinese researchers were able for the first time to bring a hybrid of pigs with cages of monkeys-primates.

Scientists continue to experiment on the creation of chimeras

How to create a Chimera?

Scientists of the State laboratory of stem cells and reproductive biology in Beijing “crossed” ordinary pig with primates of the genus Сynomolgus. The study was managed by Dr. tan Hai. He and his colleagues genetically modified the cell culture of monkey Сynomolgus, so that they could produce a fluorescent protein called GFP. This allowed the researchers to track the cells and how they develop with the formation of the body. Then they took these modified cells and injected them into embryos of pigs five days after fertilization.

This is the first successful experience of growing hybrid pigs and monkeys said Dr tan khay. More than 4000 embryos were implanted sows. The result is ten piglets, two of which were chimeras.

Unfortunately, successfully born hybridsdied within a week. As scientists have found, in chimeric pigs are a huge number of tissues including heart, liver, spleen, lungs and even the skin consisted of monkey cells, but their proportion was low: from one in 1,000 to one in 10,000.

It is unclear why the dead pigs, but since he died and nehelenia pigs, the team suspects it is related to the process of in vitro fertilization (IVF), not chimerism. ECO doesn’t work as well in pigs, as in humans and some other animals. So you need to find ways to fix it.

The world’s first pig with monkey cages

Now the team of experts tries to create healthy animals with a higher percentage of monkey cells. If it succeeds, the next step is to attempt to create pigs with one on almost completely will consist from cells of primates.

Why create chimeras?

The ultimate goal of all research of this kind is to grow human organs in animals for transplantation. But the results show that there is still a long way to go to achieve this.

For example, something similar has already been achieved in 2010. Then a Japanese scientist hiromitsu is the Executive of Nakauchi, now working at Stanford University in California have created mice with pancreas of rats by genetic modification of mice to their own cells could not develop into the pancreas and the body “belonged” to another view.

See also: People-chimeras: the era of "post-nature" is a strange and beautiful

In 2017, the team of Juan Carlos Izpisua Belmonte from the Salk Institute in California have created the Chimera of pig and human, but then only one cell per 100,000 was human, and for ethical reasons, the embryos were allowed to develop for only one month. This is due to the fact that according to one theory the brain of the Chimera can be “partially human”, and hence possess a person’s mind. That’s why Hai and his team used a monkey and not human cells. Do you think such experiments ethical? Write your thoughts in our chat in Telegram.

Given the extremely low “chimeric efficiency” and kill all the animals, I actually find it quite discouraging. — comments on the results of the Chinese team biologist Paul Knopfler from the University of California at Davis, focusing on the use of stem cells.

A number of scientists still believes that someday it will be possible to grow in the body other type of organs suitable for transplantation to man. However, it makes sense to continue investigation of this approach along with other until, until you find the optimal way to create organs for transplant.

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