Scientists have long observed a clear relationship between obesity and depression. It may seem that they are linked only by the complexes of the human about their excess weight, but no — a new study has shown that in this case also involved complex biological processes. So, the researchers from the University of Glasgow found that symptoms of depression may arise when people consume dietary fats accumulate in a certain area of the brain.
In 2018, a study was conducted in which mice were given food with high fat content. Subsequently, these individuals began to show symptoms of depression for as long as antibiotics have not returned to the state of the microflora to normal. Then the researchers came to the conclusion that a diet high in fat can cultivate certain groups of intestinal bacteria that cause leading to depression neurochemical changes.
The new study moved from the study of the intestinal bacteria, and identified the processes that occur in the human brain. At the beginning of the experiment on mice it was discovered that depressed behavior results as a dietary and genetically induced obesity. In a more detailed study revealed that dietary fats easily enter the bloodstream and accumulate in the region of the brain called the hypothalamus. Subsequently, they cause disturbances in signal pathways, which becomes a cause of depression.
This is the first case when somebody has observed a direct effect of a diet high in fat to signal the brain areas related to depression, explained George Bailey, the study’s lead author.
New discovery explains why suffering from obesity patients respond worse to the antidepressants than thin patients. Learning of this, the researchers can create drugs that cure depression by influencing quantity of fatty acids in the blood.
We often eat fatty foods to console myself because it is really tasty. However, in the long term, such foods can affect a person’s mood very negatively.
In April, scientists also learned that obesity can lead to the destruction of the brain. Details of this study can be found in our material.
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