The contribution of Stephen Hawking in science cannot be underestimated, as his zeal for life. As you know, the famous scientist suffered from a difficult treatment of the disease called “amyotrophic lateral sclerosis”, which ultimately was the cause of the death of Stephen. The disease annually kills many lives and, quite possibly, a team of researchers from the Weizmann Institute (Israel) discovered how to cure serious illness. At least, preliminary data suggests that’s about it.
What is amyotrophic lateral sclerosis?
Amyotrophic lateral sclerosis (abbreviated ALS) is a slowly developing disease that is characterized by progressive lesions of the motor departments such as the brain and spinal cord. As a result, the person gradually develop paralysis and later atrophy of the muscles. Manifestations of the disease gradually “grow”. And if at first refuse the muscles of the extremities, that eventually begin to not work and other types of muscle. As a result of a patient suffering from ALS, death occurs from respiratory tract infections or from failure of the respiratory muscles. As a rule, patients with als do not live more than 3-5 years after diagnosis.
But in rare cases the patient can be stabilized and the disease slows or stops altogether. This is what has allowed Stephen Hawking to live a long life. Another illustrative example is an American rock musician Jason Becker, who lives with als since 1989 to this day.
What occurs in amyotrophic lateral sclerosis
The exact causes remain unclear. It is known that there are both hereditary and acquired forms of the disease, but new data suggest that the disease may respond to the condition of the gastrointestinal tract. It seems that between the digestive tract and the nervous system there is no connection. But it only at first sight, say scientists from Israel.
A group of researchers from the Weizmann Institute in the course of the study populations of rodentsaffected with a form of BASS, found that mice with a predisposition to the disease feel much worse when the microflora of their intestine was virtually destroyed by antibiotics. In mice with almost destroyed microflora, the symptoms of amyotrophic lateral sclerosis manifested faster than in rodents with normal condition of the gastrointestinal tract.
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Then the researchers analyzed the bacterial composition of the stomach and intestines of healthy mice and mice with a predisposition to the BASS and figured out 11 of the most common strains of bacteria that were present in each group. After that, they found that the bacterium Akkermansia muciniphila was isolated a lot of a substance called nicotinamide. It wouldn’t be nothing nothing not normal, but the fact that nicotinamide significantly slows the disease and improves the functioning of the Central nervous system.
At the same time, scientists did not stop there and has studied the condition of the gut microbiota of 37 patients with als. They found that all patients had low levels of nicotinamide in the blood. Moreover, when experts are introduced into mice suffering from BASS nicotinamide, their condition has improved significantly.
A cure for amyotrophic lateral sclerosis found?
This is a very difficult question. On the one hand developed by scientists from Israel the drug works. And this is confirmed by the data obtained in the course of the research. On the other hand a full human studies have not yet been. Besides, one cannot rule out the existence of remote side effects of the drug in the future. Scientists also warn that their findings should not be taken as a “call to action”. However, if balinaise tests succeed, the finished product can be expected on the market in a few years.
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