Report of the Finnish scientists on the five-year study of options for the treatment of acute appendicitis with appendectomy (removal of Appendix) and antibiotics, says about the effectiveness of the latter method. The results of a study published in the journal JAMA. Observations showed that of the 256 persons treated with antibiotics, more than half in the next 5 years did not need surgery.
The assumption that use of antibiotics may be sufficient for the treatment of uncomplicated acute appendicitis were deduced in earlier studies. Observations showed that in the absence of perforation (rupture) of the Appendix antibiotics can significantly improve the patient’s condition. However, all attempts clinical tests had limitations – low, small sample.
Collect more data decided, a team of scientists from the University of Turku (Finland). The researchers conducted a random sample of 530 patients with acute appendicitis aged 18 to 60 years and divided them into two groups. One group, consisting of 273 people, was the standard procedure of removing the Appendix. The second group of 257 people for three days intravenously administered tigecycline. After that, patients during the week was taking levofloxacin and metronidazole.
After study participants were treatment and a course of antibiotics, scientists observed them for a further five years. The researchers wanted to determine how many repeated cases of inflammation and complications after treatment with antibiotics is observed in patients. At the end of the study, the researchers summarized the results: among those who were treated with antibiotics, 70 people in the first year after treatment and another 30 over the next five years of observations needed surgery. At 24.4 percent of people after appendectomy and 6.5% after treatment with antibiotics during the observed period there were some complications (abdominal pain, inflammation of the surgery site and surgery). At the same time, the researchers noted that the period of recovery after treatment with antibiotics, people were on average 11 days faster than those who passed the procedure of appendectomy.
According to the researchers, their findings show the high potential of non-surgical method of treatment of appendicitis. At the same time, scientists note that all of the studied in this work cases of inflammation of appendicitis were not of extreme form, in which sometimes for the survival of the patient requires immediate surgical intervention.
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