Aging is a natural process, which, unfortunately, will not go away. All living organisms are arranged in such a way that sooner or later they begin to “exhaust their resources and fade”. But this does not mean that we should not fight or at least to study such mechanisms. And sometimes discoveries in this area can not seriously surprising. For example, recently a group of researchers from Singapore have found a link between the speed of aging and condition of intestinal microflora.
As the microflora associated with aging?
An international research team led by Nanyang technological University, Singapore (NTU Singapore) have discovered that the microorganisms living in the gut can affect the aging process, which can lead to the development of treatments based on the food. All living organisms, including humans, coexist with billions of microbes living both outside and inside. The study, which took 20 years, found that intestinal bacteria play an important role in nutrition, physiology, metabolism and even the aging process. Using laboratory mice, the team led by Professor Sven Pettersson, transplanted intestinal germs old mice (they were 24 months) young (age 6 weeks), which microflora was not so “old”.
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A team of scientists showed that the activity of the nervous system due to the enrichment of intestinal microbesthat produce specific short-chain acid belonging to the class butyrate (which is nothing to do with “the” butyrate not have). Butyrate produced by microbial fermentation of dietary fibers in the lower intestine and stimulate the production of the hormone FGF21 longevity, which plays an important role in the regulation of energy and metabolism of the body. With age, its production decreases.
It turned out that bacteria from the older mice were able to support the development of the nervous system in young. And now we can simulate neurostimulatory effect, only using the analogue of butyrate. the Professor said Pettersson. This is an amazing and very interesting observation. These results lead us to study whether the microbiota indirectly support a further recovery in situations such as stroke, spinal cord injury and aging.
The team also examined the influence of transplanting the gut microbes from the old to the young mice on the functions of the digestive system. With age, the viability of cells of the small intestine is reduced, and it is associated with decreased production of mucus, which makes intestinal cells more vulnerable to damage. However, the addition of butyrate helps to regulate the function of intestinal barrier and reduce the risk of inflammation.
Scientists have discovered that mice treated with microflora from old donors had longer villi of the intestine. The discovery shows that gut microbes can compensate and maintain the aging body with positive stimulation. This indicates a new potential method of dealing with the negative consequences of ageing by simulating the enrichment and activation of butyrate. Want to know more? Subscribe to our page in Yandex.Zen.
We can imagine future human studies where we will test the ability of food to prevent aging.
Interestingly, microbes elderly animal feel better in young individuals. This suggests that the microflora in the aging process modificeres in order to compensate for the accumulating deficit in the host body. The obtained results contribute to the understanding of the relationship between the microbiome and its host, and lay the Foundation for the development of methods and medications related to the maintenance of correct work of the microflora and combat aggravation.